The Tupelo Micropolitan Statistical Area is a micropolitan area in northeastern Mississippi that covers three counties—Itawamba, Lee and Pontotoc.

As of the census[1] of 2000, there were 125,251 people, 48,070 households, and 34,881 families residing within the μSA.

The racial makeup of the μSA was 79.37% White, 18.98% African American, 0.16% Native American, 0.37% Asian, 0.01% Pacific Islander, 0.47% from other races, and 0.64% from two or more races.

Hispanic or Latino of any race were 1.27% of the population.

Males had a median income of $29,781 versus $21,495 for females.