The show employed an alternating rotating company of actors: David Niven, Robert Ryan, Jane Powell, Jack Lemmon and Charles Boyer during its initial season.

[3] The series continued to feature the talents of veteran and emerging actors over the ensuing years, including Cliff Robertson, John Cassavetes, Brandon deWilde, Cornel Wilde, Agnes Moorehead, Jack Carson, Walter Slezak and Gary Merrill.

Child actor Flip Mark made his television debut as Robbie Adams in the 1959 episode "Another Day Another Dollar".

"333 Montgomery" (June 13, 1960) starred DeForest Kelley in the pilot episode of an unsold series written by Gene Roddenberry.

Jack Lemmon, William Talman and Joan Blackman starred in "The Victim," a suspense episode involving a disappearing woman.