)[11] She performed in his The Mercury Theatre on the Air radio adaptations, and had a regular role opposite Welles in the serial The Shadow as Margo Lane.

[15] Moorehead played another strong role in The Big Street (1942) with Henry Fonda and Lucille Ball, and then appeared in two films that failed to find an audience, Government Girl (1943) with Olivia de Havilland and The Youngest Profession (1944) with adolescent Virginia Weidler.

"[16] In 1943–1944, Moorehead portrayed "matronly housekeeper Mrs. Mullet", who was constantly offering her "candied opinion", in the Mutual Broadcasting System's The Adventures of Leonidas Witherall; she inaugurated the role on CBS Radio.

[17] Throughout her career, Moorehead skillfully portrayed puritanical matrons, neurotic spinsters, possessive mothers, and comical secretaries.

She had supporting roles in The Youngest Profession (1943), Since You Went Away (1944), and the crime drama Dark Passage (1947), starring Humphrey Bogart and Lauren Bacall.

She played Parthy Hawks, wife of Cap'n Andy and mother of Magnolia, in MGM's hit 1951 remake of Show Boat.

Moorehead's most successful appearance on Suspense was in the play Sorry, Wrong Number, written by Lucille Fletcher,[18] broadcast on May 18, 1943.

Moorehead played a selfish, neurotic woman who overhears a murder being plotted via crossed phone wires and eventually realizes she is the intended victim.

Moorehead's title character was described as "the lively widow of a department store owner who has a tongue as sharp as a hatpin and a heart as warm as summer.

"[21] Moorehead played one of her last roles on January 6, 1974, as Mrs. Ada Canby in the ironically titled "The Old Ones Are Hard to Kill", the inaugural episode of CBS Radio Mystery Theater.

Her role in the radio play Sorry, Wrong Number inspired writers of the CBS television series The Twilight Zone to script an episode with Moorehead in mind.

[24] In "The Invaders" (broadcast January 27, 1961), Moorehead played a woman whose isolated farm is plagued by mysterious intruders.

Moorehead also had guest roles on Channing, Custer, Rawhide in "Incident at Poco Tiempo" as Sister Frances, and The Rifleman.

[18] In 1964, Moorehead accepted the role of Endora, Samantha's (Elizabeth Montgomery) mortal-loathing, quick-witted witch mother in the situation comedy Bewitched.

She later commented that she had not expected it to succeed and that she ultimately felt trapped by its success, but she had negotiated to appear in only eight of every 12 episodes made, thus allowing her sufficient time to pursue other projects.

Prior to her death in 1974, she said she had enjoyed playing the role enough, but it was not challenging and the show itself was "not breathtaking", although her flamboyant and colorful character appealed to children.

"[16] In fall 1964, Moorehead participated in a 5-minute commercial spot featuring casts of both Bonanza and Bewitched, announcing the new 1965 Chevrolet line.

In 1970, Moorehead appeared as a dying woman who haunts her own house in the early Night Gallery episode "Certain Shadows on the Wall".

She also reprised her role in Don Juan in Hell on Broadway and on tour, with an all-star cast that featured Edward Mulhare, Ricardo Montalbán, and Paul Henreid.

For the 1973 Broadway adaptation of Gigi, Moorehead portrayed Aunt Alicia and performed various songs, including "The Contract" for the original cast recording.

[30] Paul Lynde, Moorehead's co-star on Bewitched, stated: "Well, the whole world knows Agnes was a lesbian - I mean classy as hell, but one of the all-time Hollywood dykes".

[31] Journalist Boze Hadleigh reported an incident, also sourced to Lynde, in which, when she caught one of her husbands cheating on her, "Agnes screamed at him that if he could have a mistress, so could she.

"[32] In a 1973 interview with Hadleigh, when afforded the opportunity to either confirm or, once and for all, put to rest the rumors regarding her sexual orientation, Moorehead "wryly" opts to do neither: BH: Just one more question.

Numerous Hollywood actresses - Garbo, Gish, Dietrich, Jean Arthur, um, Kay Francis, Stanwyck, Bankhead, Del Rio, Janet Gaynor, etc., etc.

[35] Moorehead was one of many people to have developed cancer after exposure to radioactive fallout from atmospheric atomic bomb tests[36] while making The Conqueror (1956) with John Wayne in Iron City, Utah.

[38][39][40] Moorehead died at Mayo Clinic Hospital in Rochester, Minnesota, on April 30, 1974, due to uterine cancer at the age of 73.

Her family's Ohio farm went to John Brown University in Siloam Springs, Arkansas, along with her collection of Bibles and biblical scholarship materials.