Turtle Creek is a tributary of the West Branch Susquehanna River in Union County, Pennsylvania, in the United States.

The main surficial rock types in the creek's watershed include shale, carbonate, and sandstone.

The creek then turns north for several tenths of a mile and enters a much broader valley and receiving an unnamed tributary from the left.

At this point, it turns east-northeast for several miles, entering East Buffalo Township and receiving three unnamed tributaries from the right.

A short distance further downstream, it reaches its confluence with the West Branch Susquehanna River.

[1] Turtle Creek joins the West Branch Susquehanna River 4.60 miles (7.40 km) upriver of its mouth.

No sediment comes from [3] The average annual rate of rainfall in the watershed of Turtle Creek over a 23-year period was found to be 42.1 inches (107 cm).

[9] Turtle Creek was entered into the Geographic Names Information System on August 2, 1979.

[10] Samuel Maclay carried out a survey in the vicinity of Turtle Creek in early March 1769.

[11] In 1772, John Aurand settled at the mouth of the creek and constructed a gristmill and a sawmill there in the same year.

[11] In 1795, Anna M. Smith left 30 pounds in her will to the construction of a school for poor children at the mouth of the creek.

[11] In 1853, several people from Lewisburg purchased 20 acres (8.1 ha) of land to the south of the mouth of Turtle Creek and set up the Union Furnace.

[11] A concrete tee beam bridge carrying US Route 15 was constructed over Turtle Creek in 1930 and repaired in 1962.

A prestressed box beam or girders bridge carrying T-432/Stein Lane over the creek was built in 1932 and repaired in 1984.

In 1983, a concrete culvert bridge was constructed over the creek 4 miles (6.4 km) east of Mifflinburg.

A bridge of the same type was constructed over the creek 2 miles (3.2 km) southwest of Linntown in 2000, with a length of 60.0 feet (18.3 m).

[14] Turtle Creek was described as a "[stream] of major concern" in the Union County Open Space and Recreation Plan in 1973.

[15] In late 20th century, the Union County: A Plan for Development recommended the creation of a greenway along the floodplain of Turtle Creek, running westward from the West Branch Susquehanna River.