The Tuskegee Institute Silver Anniversary Lecture was an event at Carnegie Hall on January 23, 1906, to support the education of African Americans in the South.

It involved many prominent members of New York society, with speakers including Booker T. Washington, Mark Twain, Joseph Hodges Choate, and Robert Curtis Ogden.

It was the beginning of a fund raising drive started by Booker T. Washington for the Tuskegee Institute with a goal of making up the annual operating shortfall, plant improvements, and creating an endowment.

Many New York luminaries attended: John D. Rockefeller, Henry H. Rogers, Clarence H. Mackay, Morris K. Jesup, J. G. Phelps Stokes, Isaac Newton Seligman, George Foster Peabody, John Crosby Brown, Carl Schurz, W. H. Schieffelin, William Jay Schieffelin, Joseph Hodges Choate, Henry Villard, Nicholas Murray Butler, Cleveland H. Dodge, Alfred Shaw, Felix M. Warburg, R. Fulton Cutting, Collis P. Huntington, Robert Bowne Minturn, Jr., Jacob H. Schiff, Paul M. Warburg.

William Jay Schieffelin, a progressive businessman and socialite related to the Vanderbilt family, opened the lecture and introduced Joseph Hodges Choate, who was a well known lawyer and diplomat.