The town lies in the valley of the Upper Danube on both sides of the stream, the source of which is located 30 km nearby in Donaueschingen.

Spurious archeological findings in 1874 support the theory, but due to its probable location under the foundations of houses in the town centre expansive excavations will not be done.

Starting in 1804 the town was rebuilt by master architect Carl Leonard von Uber according to classicist plans with right-angle streets and rectangular housing settlements.

A total of 3,645 victims of the so-called „Euthanasia-campaign T4" were cremated in the cemetery of the town, including murdered inmates of regional concentration camps.

As its population had already grown beyond 20,000 in 1949, Tuttlingen was declared to be "Große Kreisstadt" as soon as the Baden-Württemberg council regulations were implemented on 1 April 1956.

List of important companies: Each summer the festival "Honberg Sommer" attracts visitors to concerts with international bands, cabaret artists, and beer gardens.

The German poet Goethe wrote that the town and surrounding area has a strange and beautiful landscape, hilly with fields and patches of forest.