It is a subsidiary of Azul Brazilian Airlines, operating feeder and cargo flights connecting cities in the interior of Brazil to the parent company's hubs.

[2][3] Between August 2016 and June 2019, TwoFlex operated wet lease flights on behalf of Voe Minas Gerais, a state-run project that connected cities within the State of Minas Gerais to the State capital Belo Horizonte.

[4] In November 2017, Twoflex was granted rights to operate regular feeder passenger flights connecting smaller locations to main cities in all Brazilian territory.

[10] On August 14, 2019, the National Civil Aviation Agency of Brazil confirmed that TwoFlex was granted 14 slots at Congonhas but can only operate using the auxiliary runway 17L/35R.

[13] On March 27, 2020, the Brazilian regulatory bodies gave its full permission (nihil obstat) to the purchase[14] and sale of flights started on April 14, 2020.