Born at Calumet Farm in Lexington, Kentucky, her sire was Bull Lea whose progeny were already successful.
Her only defeat came in the Modesty Stakes against older females; in that race, she carried ten pounds more than the winner.
In the Cleopatra Stakes, Two Lea raced against another stablemate, Wistful, who was considered the East Coast's leading filly.
Two Lea shared the 1949 three-year-old female championship with Wistful, another Calumet horse, as the fillies tied in the Daily Racing Form poll.
Ridden by Eddie Arcaro for the first and last time, she contested the Santa Anita Maturity with Ponder, winner of the previous year's Kentucky Derby.
She beat Wistful again, giving her ten pounds, and then won the Hollywood Gold Cup against males.