The podcast is about Israeli life, society, and politics, and has hosted a number of prominent guests.

[7] The success of Two Nice Jewish Boys, which is self-funded, led to the creation of The Melting Podcast, which is hosted by Meningher and published by the Israeli Public Broadcasting Corporation, in 2017.

[5] The podcast has hosted a number of high-profile guests, including Michael Oren, Dan Shechtman, Chaim Topol, Ania Bukstein, Tamar Zandberg, Robert Aumann, Deborah Lipstadt, Uri Geller, and Moshe Koppel.

Weinstein posted a negative response to Oliver's criticism on the Two Nice Jewish Boys YouTube channel.

[9] In September 2024, Two Nice Jewish Boys drew criticism for an episode about the war in Gaza.