During his career he produced tracks for MC Lyte, Foxy Brown, Slick Rick, Ja Rule, Canibus, Jayo Felony, Queen Pen, Cam'ron, 54th Platoon and Royce da 5'9", remixed songs for LL Cool J, The Party, Royal Flush, Robin Thicke and Nas, and collaborated with Teddy Riley, Erick Sermon, Irv Gotti and Dr. Dre.
By the end of the 1990s, his portfolio includes works with Sermon, LL Cool J, Redman, Craig Mack, McGruff, Foxy Brown, Slick Rick, Big Pun and Murder Inc. among others.
After working on Murder Inc.'s "Murdergram" song from Streets Is Watching Soundtrack, he began to collaborate with Irv Gotti and became a recurring producer for Ja Rule albums and fellow Roc-A-Fella acts, such as Jay-Z, Amil, Cam'ron and Beanie Sigel.
After the success of "Straight to the Bank", which was co-produced with Dr. Dre, Fyffe became a recurring producer for several G-Unit projects, such as 2008 T·O·S (Terminate on Sight), 50 Cent's 2009 Before I Self Destruct and 2014 Animal Ambition albums and Tony Yayo's 2011 El Chapo mixtape.
[2] From 2010 to 2020, he produced tracks for Ghostface Killah ("Smooth Sailing", which appeared on Wu-Tang Killa Bees' Pollen: The Swarm Part Three, and its remix version was included in Wu-Massacre), Redman's 2010 Reggie, Styles P's 2011 Master of Ceremonies, Lazee's 2011 mixtape One Way Ticket, Prodigy's 2012 H.N.I.C.