He was selected by the Denver Broncos in the second round of the 2015 NFL draft, where he was a member of the Super Bowl 50 championship team after they beat the Carolina Panthers by a score of 24–10.

A native of Watsonville, California, Sambrailo attended Saint Francis Central Coast Catholic High School, where he was a two-way lineman and three-year team captain.

Sambrailo was a first-team all-state selection as a senior and was named the Santa Cruz Coast Athletic League Offensive and Defensive Lineman of the Year.

Regarded as the only two-star recruit by Rivals.com,[1] Sambrailo was not ranked among the top offensive linemen of his class, which was highlighted by Seantrel Henderson, Luke Joeckel, and Jake Matthews.

Sambrailo was the lone junior on a solid offensive line that helped contribute to the Colorado State Rams reaching the 2013 New Mexico Bowl.