He is best known for his role as Jake Brockman in the British sitcom Outnumbered, in Citizen Khan as Richard Scab before later appearing in Horrid Henry: The Movie[2] and the television series Cuckoo.

In October 2011, Drew-Honey and his co-stars from Outnumbered, Daniel Roche and Ramona Marquez, covered "(Theme From) The Monkees" to raise funds for the BBC charity campaign Children in Need.

A music video featuring them performing the song on the set of Outnumbered appeared on the Children in Need programme and was released on YouTube in November 2011.

In September 2022, Drew-Honey joined The Celebs alongside Jo O'Meara and Anne Hegerty to mark the 40th anniversary of the Michael Jackson classic album Thriller and raise money for Great Ormond Street Hospital, with a new rendition of the title track.

[11] Drew-Honey was nominated for Best Male Newcomer at the 2009 British Comedy Awards for his role in Outnumbered,[16] but lost to Charlie Brooker.