He is best known for starring in the film Tucker & Dale vs Evil, the television series Breaker High, Invasion, Reaper, Deadbeat and as Dr. Iggy Frome, head of psychiatry, in the NBC medical drama New Amsterdam.

He starred in the NBC comedy series Animal Practice alongside Justin Kirk and Bobby Lee, which premiered in September 2012.

In 2017, he played Sherlock Hobbs in the second season of Dirk Gently's Holistic Detective Agency.

From 2018 to 2023, he was part of the main cast of New Amsterdam where he played Head of Psychiatry, Dr. Iggy Frome.

[7][better source needed] He was hospitalized in July 2023 for a potentially fatal blood clot in his stomach.