The Town of Tyre is located in the northeastern part of the county, northeast of Geneva.

The primary postal district covering the area is ZIP Code 13148 for Seneca Falls.

[6] A small section of addresses west of N.Y. Route 414 to the town border have a ZIP Code of 13165 for Waterloo.

A tract at the hamlet of Tyre was granted to Revolutionary War Colonel James Livingston.

[8] Other early settlers were Asherr Halsey, Lewis Winans, Asa Smith and Caleb Woodworth.

[10] The Hiram Lay Cobblestone Farmhouse was listed on the National Register of Historic Places in 2009.

The northern town line is the border of Wayne County, and the eastern town line, partly marked by the Seneca River, is the border of Cayuga County.

New York State Thruway (Interstate 90) crosses the town, passing through the Montezuma Marsh.

New York State Route 31 crosses the northeastern corner of the town.