Tyronza is one of the oldest cities within Poinsett County with its origins dating back to the late 19th century.

In the 1930s, it was the site where the Southern Tenant Farmers movement started what became a national outcry against the abusive discrimination by wealthy land owners against the mostly African-American sharecroppers.

Tyronza was the home of Dr. L. H. McDaniel, a local physician who became friends with President Lyndon Baines Johnson through his political involvement in the Democratic Party.

He treated patients all over eastern Arkansas regardless of their ability to pay and often accepted live chickens, baked goods and garden vegetables as payment for his home visits.

[4] In 1934, the Southern Tenant Farmers Union (STFU) was formed in the town to organize local sharecroppers towards getting better arrangements from landowners.

[5] Ward H. Rogers, a Texas-born minister and labor activist, threatened to hang every plantation owner in Poinsett County, Arkansas if the demands of the sharecroppers were not met.

[6] As of the 2020 United States census, there were 716 people, 376 households, and 268 families residing in the city.