Harrisburg is a city in Poinsett County, Arkansas, United States.

According to the United States Census Bureau, the city has a total area of 2.1 square miles (5.4 km2), all land.

As of the 2020 United States census, there were 2,212 people, 1,060 households, and 748 families residing in the city.

At the 2000 census there were 2,192 people in 855 households, including 582 families, in the city.

There were 928 housing units at an average density of 444.7 per square mile (171.7/km2).