The municipality of Tzitzio is located in the Balsas Depression in northeast Michoacán at an elevation between 600 and 2,400 metres (2,000–7,900 ft).

It borders the municipalities of Charo and Indaparapeo to the north, Queréndaro to the northeast, Hidalgo to the east, Tuzantla to the southeast, Tiquicheo to the south, Madero to the west, and Morelia to the northwest.

[6] The southeastern corner of Insurgente José María Morelos National Park [es] extends into Tzitzio near its municipal seat.

[2][10] The municipal government comprises a president, a councillor (Spanish: síndico), and seven trustees (regidores), four elected by relative majority and three by proportional representation.

Major activities include cattle farming and the cultivation of corn, tomatoes, sugarcane, and fruits such as mango, guava, plum and papaya.