U-69,593 is a drug which acts as a potent and selective κ1-opioid receptor agonist.

[1][2][3] In animal studies it has been shown to produce antinociception,[1][4][5] anti-inflammation,[6] anxiolysis (at low doses),[7][8][9] respiratory depression,[5] and diuresis,[10] while having little effect on gastrointestinal motility.

[1] It also inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.

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