The United States established its consulate-general in Dacca in 1949, when the city was the capital of East Bengal in the Dominion of Pakistan.

[1][2] Herbert D. Spivack was the principal American diplomatic officer in Dhaka at the time.

[3] Four days later, the United States and Bangladesh agreed to establish diplomatic relations at the embassy level.

As part of the Foundation for Art and Preservation in Embassies, artwork by Tara Andris, Nasreen Haroon, Bernadette Jiyong Frank, Allison Joyce, Mira Lehr, Stuart Peterman, Jody Rasch, Lawrence Schiller, and Michael Enn Sirvet has been included in the Embassy as of June 2020.

A lawn filled with palm trees and a moat surrounds the main building.