US 395 is a major north–south highway serving the inland regions of the West Coast states as well as northwestern Nevada.

[3] The highway travels north across the Mojave Desert and intersects State Route 58 (SR 58) at Kramer Junction near the town of Boron and east of Edwards Air Force Base.

[4] It continues across the desert, passing several solar farms, and crosses the El Paso Mountains and Summit Range near Johannesburg.

[6] US 395 continues through the Owens Valley and follows the Los Angeles Aqueduct, which it crosses several times;[7] the highway is primarily four lanes in the area with several divided sections outside of cities.

[8] The highway traverses Lone Pine and passes the Manzanar National Historic Site, which operated as a Japanese American internment center during World War II.

[9][10] US 395 turns north after passing through Independence and reaches Bishop, where it serves as the western terminus of US 6, a transcontinental highway.

[14] The highway travels northwest along the Carson River through the Washoe Tribe's Dresslerville Colony and the adjacent towns of Gardnerville and Minden.

It then travels through the city's suburban neighborhoods and along the west side of Reno–Tahoe International Airport before a junction with I-80 east of downtown and the University of Nevada, Reno campus.

[5] The highway has been designated as the Martin Luther King Jr. Freeway from southern Reno to the California state line since 1998.

The highway continues northwest to avoid Honey Lake and reaches an intersection with SR 36 near Susanville, where it turns east.

The highway continues along the South Fork Pit River into the city of Alturas, where it serves as a main street until a junction with SR 299.

US 395 continues north along the shore of Goose Lake and reaches the Oregon state line in the community of New Pine Creek.

Approximately two miles (3.2 km) northeast of Burns, US 395 turns north through Seneca and Canyon City to John Day.

[citation needed] The entire route within Oregon was designated as the World War I Veterans Memorial Highway in 2015.

[18] The four-lane divided highway carries US 395 northeast around several small towns towards Ritzville, where it merges with I-90 and begins a 60-mile (97 km) concurrency.

It had also followed Pomerado Rd through Poway prior to the construction of the freeway, and entered Escondido along Centre City Parkway, which today exists as a business route.

The newer route continued north more directly from Escondido, paralleling I-15 along several frontage roads (some sections of which are named "Old Highway 395") to bypass Vista and Fallbrook.

The state legislature passed a resolution in 2008 to recognize portions of Historic US 395; by 2011, over 100 signs had been installed by private groups along the former alignment, mostly in San Diego County.

[20][21] Work to rebuild other two-lane sections has continued into the 21st century, with a 12.6-mile (20.3 km) bypass of Olancha near Owens Lake planned to be constructed in the 2020s.

Today, the entire route of US 395 from Pasco to Ritzville, WA is four lane divided, but still with farm road crossings in places.