From Farmington, U.S. Highway 55 headed westward to Burnsville via present-day 212th Street West, Lakeville Blvd, 210th Street West, Kenwood Trail, and Burnsville Parkway to Lyndale Ave (now Interstate 35W).

Following the decommissioning of U.S. Highway 55, the portion of the route between Farmington and Burnsville was subsequently designated as a portion of Minnesota Highway 50, and transferred to County control in 1994 as Dakota County Road 50.

When the route was designated in 1926, its northern terminus was in Minneapolis at an intersection with U.S. Highway 12, near the Mississippi River.

While US 61 followed a more direct route from Dubuque to Davenport, the new US 55 extension followed the western shore of the Mississippi River.

The northern half of this stretch was co-signed with an extension of U.S. Highway 52, which took over the US 55 designation to Hampton, Minnesota.