There are currently four active coin-producing mints: Philadelphia, Denver, San Francisco, and West Point.

It operates mint facilities in Philadelphia, Denver, San Francisco, and West Point, New York, and a bullion depository at Fort Knox, Kentucky.

Official Mints (Branches) were once also located in Carson City, Nevada; Charlotte, North Carolina; Dahlonega, Georgia; New Orleans, Louisiana; and in Manila, in the Philippines.

[4] It converted precious metals into standard coin for anyone's account with no seigniorage charge beyond the refining costs.

[9] In 1911 the Mint had a female acting director, Margaret Kelly, at that point the highest paid woman on the government's payroll.

[14] Philadelphia is also the site of master die production for U.S. coinage, and the engraving and design departments of the Mint are also located there.

By the turn of the century, the office was bringing in over $5 million in annual gold and silver deposits, and in 1906, the Mint opened its new Denver branch.

The San Francisco branch, opened in 1854 to serve the goldfields of the California Gold Rush, uses an S mint mark.

[18] In 1968, it took over most proof-coinage production from Philadelphia,[19] and since 1975, it has been used almost exclusively for proof coinage, with the exceptions of the Anthony dollar (1979–1981),[20] a portion of the mintage of cents in the early 1980s, (these cents are indistinguishable from those minted at Philadelphia), and a small portion of America the Beautiful quarters minted in circulation-quality (but not issued for circulation) since 2012.

[23] Along with these, which were identical to those produced at Philadelphia, West Point has struck a great deal of commemorative and proof coinage bearing the W mint mark.

[24] The West Point facility is still used for storage of part of the United States' gold bullion reserves, and West Point is now the United States' production facility for gold, silver, platinum, and palladium American Eagle coins.

[22] In 2019, West Point produced limited quantities of circulating quarters bearing the "W" mint mark for the first time.

Its primary purpose is for storage of the United States and other countries' gold and silver bullion reserves.

Larger denominations of gold and silver coins were labeled with the Dahlonega, Charlotte, and New Orleans mintmarks (D, C, and O, respectively) on the obverse (front) side, just above the dates, in those two years.

Due to a shortage of nickel during World War II, the composition of the five-cent coin was changed to include silver.

To mark this change, nickels minted in Philadelphia (which had featured no mintmarks until then) displayed a P in the field above the dome of Monticello.

The circulating cents struck in the 1980s at San Francisco (except proofs) and West Point also bears no mintmark, as their facilities were used to supplement Philadelphia's production.

[41] For 2017, in commemoration of the U.S Mint's 225th Anniversary, the P mintmark was placed on the obverse of Philadelphia-minted Lincoln cents for the first time in the coin's 100+ year history.