U.S. Newswire was a U.S. national news release wire service established in 1986 which distributed media materials for a variety of customers, particularly the U.S. government and non-profit agencies.

U.S. Newswire was based in Washington, D.C. and was acquired from Medialink by PR Newswire on October 1, 2006.

Following its acquisition, U.S. Newswire was renamed PR Newswire Public Interest Services and eventually, in 2014, shut down as a separate division with operations merged into the parent company's general operations.

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