As US 127 continues north, it passes one block west of Washington Park and Findlay Market in Over-the-Rhine and marks the neighborhood's western boundary.

Upon passing the eastern end of the Western Hills Viaduct, the roadway closely parallels Interstate 75 (I-75) for nearly two miles (3.2 km).

[3] Approximately seven miles (11 km) north of Eaton, US 127 intersects I-70 and US 40 (National Road) and proceeds to Greenville.

Approaching Greenville, the road widens to a four-lane limited access highway, serving as a bypass to the east of the city.

Just north of Celina, the highway intersects US 33, which connects Ft. Wayne, Indiana, with Columbus, and then US 127 continues to Van Wert.

In Van Wert, US 127 is Washington Street and serves as the main road through the city's business district.

In Paulding, US 127 bends to the northwest to cross Flatrock Creek before reaching the courthouse and turning back to the north on Williams Street.

US 127 intersects US 6, the Grand Army of the Republic Highway and with State Route 15 (SR 15) becomes Main Street in Bryan.

At the northern city limit, SR 15 continues north to the Ohio Turnpike while US 127 begins a northeast route toward West Unity.

[3] By 1912, the current US 127 corridor in Ohio existed as a series of inter-county highways running from Cincinnati to Michigan.