US 127/SR 28 then has an intersection with US 70N/SR 24 before going through Crossville's main business district and crossing the Obed River and coming to an interchange with I-40 (exit 317).

It then crosses into Fentress County via a couple of sharp switchbacks, in order to negotiate a bridge over Clear Creek.

The highway then leaves Jamestown, at the other end of Main Street (Old US 127/SR 28), and continues north and narrowing to two lanes, winding its way through rural and hilly terrain for several miles.

Alvin C. York State Historic Park and Pall Mall, where the highway crosses the Wolf River, before passing through Forbus and having an intersection with Caney Creek Road (connector to Kentucky Route 200).

[2] US 127's current alignment was signed solely as SR 28 until the US 127 corridor's southern terminus was relocated to Chattanooga when the US route was extended south from Cincinnati, Ohio.

[citation needed] In 1987, the entire alignment of US 127 in Tennessee and Kentucky became the main route for the first annual 127 Corridor Sale.

The yard sale route has since extended into other areas along US 127 into Ohio, as well as varied state highways in southern Hamilton County, and into northwest Georgia and northeast Alabama.