The road passes through a mix of farmland and woodland with some residential and commercial development in the southern part of Suffolk, making a turn to the east in Somerton Historic District.

The route curves northeast and reaches the community of Whaleyville, where it passes a mix of homes and businesses and crosses Mineral Spring Road.

[1][2] US 13 heads northwest on the freeway to bypass central Suffolk to the west, passing through wooded areas with nearby development and coming to a bridge over Norfolk Southern Railway's Franklin District railroad line.

The freeway reaches an interchange with SR 10/SR 32 and heads between residential neighborhoods to the north and woods to the south, coming to a bridge over the Nansemond River.

[1][2] Along this stretch, US 13/US 58/US 460 cross into the city of Chesapeake and continue through wooded areas with some commercial development, passing to the south of Hampton Roads Executive Airport.

The road passes homes and businesses in the community of Bower's Hill, curving southeast into wooded areas and coming to a bridge over an abandoned railroad grade.

The two routes continue past commercial development with some homes and woodland, turning to the east and coming to an interchange with I-64 (Hampton Roads Beltway).

[1][2] US 13 enters the city of Virginia Beach and heads through more business areas, widening to six lanes and crossing Providence and Indian River roads.

Past the latter intersection, the road widens to eight lanes and curves to the north, passing between residential areas to the west and commercial development to the east.

The route comes to a bridge over the Eastern Branch Elizabeth River, at which point it enters the city of Norfolk and runs near homes before passing commercial development.

US 13 passes over Hampton Roads Transit's Tide Light Rail line east of Military Highway station before it comes to a cloverleaf interchange with I-264.

Past this interchange, the divided highway turns northeast and widens to eight lanes, passing to the southeast of the entrance to Norfolk Premium Outlets before crossing into the city of Virginia Beach.

US 13 narrows to six lanes and curves east, heading through wooded residential areas and passing between Little Creek Reservoir to the north and Lake Smith to the south.

Following this, the route curves northeast and reaches a diamond interchange with US 60, where it turns to the north and narrows to four lanes, passing between residential neighborhoods.

The roadway leaves the tunnel at another artificial island, at which point it resumes along a pair of low-level trestle bridges carrying two lanes in each direction.

The road leaves the tunnel on another artificial island and returns to a pair of low-level trestle bridges carrying two lanes in each direction.

The road intersects the southern terminus of SR 600 west of the Eastern Shore of Virginia National Wildlife Refuge and runs through a mix of farmland and woodland with some residential and commercial development a short distance to the east of the Chesapeake Bay.

[1][2] US 13 enters Accomack County and heads north-northeast through a mix of fields, woods, and commercial development as the abandoned Bay Coast Railroad line again closely parallels the route to the east.

US 13 enters the town of Painter, where it transitions into a five-lane road with a center left-turn lane and passes near a mix of homes and businesses, reaching an intersection with the western terminus of SR 182.

The road reaches the town of Keller, where the median turns into a center left-turn lane and it heads near businesses, coming to a junction with SR 180.

The route runs through more woods before it reaches the town of Melfa, where it becomes a five-lane road with a center left-turn lane and passes a mix of homes and businesses, crossing SR 626.

[1][2] South of the town of Onley, the road passes to the east of Nandua High School as it curves north away from the abandoned railroad tracks.

In the community of Nelsonia, US 13 becomes a five-lane road with a center left-turn lane and runs past homes and businesses, reaching an intersection with SR 187.

Upon reaching the community of Mappsville, the median of the road turns into a center left-turn lane and it runs near residences and commercial development, forming a brief concurrency with SR 689.

The route bends to the north-northeast and passes east of a Tyson Foods chicken plant before it reaches the community of Temperanceville, where it transitions into a five-lane road with a center left-turn lane and is lined with homes and some businesses, curving north and crossing SR 695.

At this point, the road heads into the community of Oak Hall and the median turns into a center left-turn lane as it passes through residential areas.

The route turns back into a four-lane divided highway as it runs past businesses and comes to an intersection with the western terminus of SR 175, which heads east to the town of Chincoteague and Assateague Island.

The route passes a pair of weigh stations located on both sides of the road and runs through the community of New Church, where it heads past a mix of homes and businesses and intersects SR 709.