The majority of the route within Maryland is a four-lane divided highway that passes through rural areas of woodland and farmland.

It formed a part of the Ocean Highway, a road that connected the New York City area to Florida, and still carries that name for much of its route in Maryland.

It continues north through wooded areas before heading into a mix of farmland and woodland with some residences and businesses along the road.

[1] The route crosses MD 366 (Stockton Road), which itself has its western terminus at US 13 Bus., and continues north past a shopping center before coming to a junction with the southern terminus of US 113 (Worcester Highway) and MD 250A (Old Virginia Road) along the eastern edge of town.

[2] Upon crossing the Pocomoke River, US 13 heads into Somerset County and intersects the northern terminus of US 13 Bus.

It features an intersection with the eastern terminus of MD 667 (Rehobeth Road), and the route continues from farmland into heavy woodland.

US 13 heads back into agricultural areas where it intersects many unsigned suffixed segments of MD 920 which are mostly short, dead-end roads.

[2] From here, the road heads north through a mix of woods and farms, running a short distance to the west of the Delmarva Central Railroad.

[2] It is eventually paralleled to the west by the main segment of unsigned MD 920 (Market Lane), which serves as a frontage road.

[2] Farther north, the route passes to the west of Washington Academy and High School on the other side of the railroad tracks.

[1][2] Skirting the western edge of the town, the route intersects MD 363 (Deal Island Road/Manokin Avenue) before crossing the Manokin River.

[1][2] The next intersection is with the western terminus of MD 822 (UMES Boulevard), which heads east to provide access to the University of Maryland Eastern Shore campus.

[2] US 13 reaches a junction with the northern terminus of MD 529, a rural route that heads south back to Princess Anne on Loretto Road.

[2] US 13 crosses the Passerdyke Creek into Wicomico County, where it continues northeast as South Fruitland Boulevard through a mix of woods and farms.

[1][2] Bypassing the Salisbury area to the east, the route heads through farmland and meets MD 513 (St. Lukes Road) at a diamond interchange.

Continuing northeast through a mix of farmland and woodland, with some housing developments nearby, US 13 meets MD 12 (Snow Hill Road) at a partial cloverleaf interchange.

It heads to east of the Wicomico County Tourist Information Center and passes by a set of weigh stations located on both sides of the road before it intersects the southern terminus of a separate MD 675, which follows US 13's original route through Delmar on Bi-State Boulevard.

[1][2] US 13 continues north as a four-lane highway (with two lanes in each direction), through a mix of farms and woods with some businesses, skirting Delmar to the east.

[2] The original north–south highway through Fruitland and Salisbury followed Allen Road north from Allen on Wicomico County's border with Somerset County to near the present intersection of Division Street and Camden Avenue on the west side of Fruitland.

[5] The state road was completed from the southern limit of Salisbury to Main Street in Fruitland in 1912 and from there to Allen in 1913.

[6] The highway between the Virginia border through Pocomoke City to Westover and between Salisbury and Delmar was completed by 1921.

[14] The third and final section, from Main Street to Zion Road on the north side of Salisbury, was completed by 1942.

[38] The next major upgrade to US 13 was the construction of the limited-access Salisbury Bypass beginning from the northern end around 1973.

is a business route of US 13 that passes through Pocomoke City in Worcester and Somerset counties in Maryland.

The route begins south of Pocomoke City; US 13's four-lane divided mainline curves away to the right around the town, while US 13 Bus.

After intersecting MD 366, the route connects with the original southern terminus of US 113, the latter having been rolled back to terminate at mainline US 13.

After crossing the river, the route heads out of town into rural surroundings before terminating on US 13 at the southern terminus of MD 364.

The highway runs 8.14 miles (13.10 km) between US 13 south of Fruitland and US 13 and US 50 on the north side of Salisbury.