U.S. Route 169 (US 169) is a north-south U.S highway that currently runs for 966 miles (1,555 km) from the city of Virginia, Minnesota, to Tulsa, Oklahoma, at Memorial Drive.

A segment runs around Chanute is a freeway with fully controlled access with center concrete barrier, with two lanes in each direction.

It was identified as a high crash location in 2001, and was rebuilt as a roundabout that opened in April 2006.

From this point to the Missouri state line, US 169 alternates between freeways and surface streets.

It follows I-35 to Shawnee Mission Parkway in Overland Park, then travels east to Rainbow Boulevard.

[4] US 169 exits I-70 shortly after both roads enter Missouri via the Lewis and Clark Viaduct.

It crosses the Missouri River by the Buck O'Neil Bridge and serves Kansas City Downtown Airport.

An at-grade private driveway exists just south of the intersection with Route 9 as well as for airport access.

At the northern end of the city, an intersection was reconstructed at NE 108th Street in November 2013.

In St. Joseph, it forms most of the Belt Highway, a major commercial strip on the eastern edge of town, paralleling just inside I-29.

US 169 angles northeastward out of St. Joseph, passing through many rural communities before exiting Missouri north of Grant City.

This is changing, however, as a two-phase, $11 million project began in the spring of 2010 to widen the route to four lanes from Fort Dodge to Humboldt.