U.S. Route 19 (US 19) traverses approximately 11.8 miles (19.0 km) across the Tri-Cities area of East Tennessee.

US 19E heads southeast toward Elizabethton and US 19W continues southwest concurrent with US 11E toward Johnson City.

US 19 heads north concurrent with US 11E along Volunteer Parkway across the South Fork Holston River.

SR 34 breaks from its unsigned concurrency with US 11E and US 19 and heads east on US 421 toward Mountain City.

US 19 first appears in Tennessee in 1927, from the North Carolina state line (near Elk Park) to Bluff City.