U.S. Route 22 (US 22) is a United States Numbered Highway stretching from Cincinnati, Ohio, in the west to Newark, New Jersey, in the east.

For the remainder of the route, US 22 runs to the south of I-78 through mostly suburban areas as a four- to six-lane arterial road, passing through Hunterdon, Somerset, Union, and Essex counties.

US 22 enters New Jersey from Easton, Pennsylvania, on the Easton–Phillipsburg Toll Bridge over the Delaware River and Norfolk Southern Railway's Portland Secondary line.

[2] It heads into Phillipsburg, Warren County, as a four-lane undivided freeway maintained by the Delaware River Joint Toll Bridge Commission (DRJTBC).

[1] From the previous exit, US 22 runs eastward as a four-lane divided freeway maintained by the New Jersey Department of Transportation (NJDOT) that ends in an interchange with Morris Street and Hillcrest Boulevard.

[1] At this point, the route becomes at-grade Memorial Boulevard; a commercial four to six-lane arterial road with a wide median consisting of U-turn ramps and jughandles.

[1][2] I-78/US 22 follow a six-lane freeway east through Greenwich Township, coming to a westbound exit and eastbound entrance with CR 637.

[1][2] Upon splitting from I-78, US 22 becomes a four-lane arterial road that runs through rural areas with some development and crosses NJ Transit's Raritan Valley Line.

Here, the road passes to the southwest of the Merck Headquarters Building before reaching the community of Whitehouse Station, where it has a short concurrency with CR 523.

[1] Past this interchange, US 22 passes business parks and the Raritan Valley Country Club, widening to six lanes in the process.

The median of the route widens as it runs immediately to the south of I-287, fully entering Bridgewater Township again as it comes to an interchange with I-287 at exits 14A and 14B.

[2] The road comes to an interchange with CR 675, where it also passes under Norfolk Southern Railway's Middle Brook Industrial Track line.

The road continues through wooded surroundings and passes through a portion of Bound Brook, widening back to six lanes before meeting CR 527 at an interchange.

Past this interchange, the road continues along the border of Watchung to the west and North Plainfield to the southeast before crossing Green Brook.

[1][2] Past this interchange, the route comes to an exit for CR 630 before crossing the Elizabeth River into Hillside, where it heads east through more urban areas.

[1][2] The road has an interchange at Bloy Street before passing over CR 509 and Conrail Shared Assets Operations (CSAO)'s Irvington Industrial Track line.

Past the park, US 22 turns to the east into urban areas and closely runs to the south of I-78, where it comes to an eastbound exit and westbound entrance for Empire Street, which provides access to Route 27.

[2][3] The portion of US 22 between Phillipsburg and Somerville roughly follows the alignment of the Jersey Turnpike, which was chartered in 1806 to run from New Brunswick to Philipsburg.

[5] The portion of the modern route that now enters Philipsburg was originally part of the Washington Turnpike, before being incorporated into the William Penn Auto Trail by 1916.

[7][8] When the U.S. Numbered Highway System was established in 1926, US 22 was designated through New Jersey from the Northampton Street Bridge in Phillpsburg and followed Route 9 east to US 1/9 in Elizabeth.

[20] The former alignment between Alpha and Clinton became Route 173 while the portion east of there became county-maintained Beaver Avenue (currently designated CR 626).