From this interchange, US 24 proceeds southeast through Minturn and continues south to the Continental Divide at Tennessee Pass.

After the pass, US 24 separates from US 285 and continues east to Colorado Springs and then northeast to Limon, where US 24 joins I-70 for most of the rest of its routing to the Kansas state line.

In Kansas, US 24 is merged with US 59 from Williamstown to a place in northern Lawrence called Teepee Junction.

After becoming a two-lane road, it is then concurrent with Route 5 in Keytesville (where it is called Jackson Street) and then passes by the city of Huntsville before turning into a four-lane highway and crossing US 63 at Moberly.

It is finally concurrent (for the third time) with US 36 east of Monroe City and with US 61 from south of Palmyra to West Quincy.

The segment of US 24 between Logansport and Toledo, Ohio, is part of the Hoosier Heartland Industrial Corridor project of the Intermodal Surface Transportation Efficiency Act.

Between the Indiana state line and Toledo, this portion of the roadway is known as the Fort to Port segment of the Hoosier Heartland Industrial Corridor.

At a point on Toledo's north side, US 24 veers from northeast–southwest to true north–south, turning on to Telegraph Road, while Detroit Avenue continues as a city street that connects to M-125 (Dixie Highway) at the Michigan border.

In Michigan, US 24 enters from Toledo, Ohio, and serves the city of Monroe and Metro Detroit, where it is known as Telegraph Road.

It passes through Michigan's "mixing bowl", which is where I-696 (Walter P. Reuther Freeway), M-10 (John C. Lodge Freeway/Northwestern Highway), and Lahser Road intersect.

US 24 continues north along Telegraph Road as the border between Waterford and Pontiac until its intersection with Dixie Highway where it travels to the northwest until its termination at I-75 in Independence Township.

Several other channelization techniques are also used; for instance, the M-153 (Ford Road) intersection includes a southbound jughandle and a cutoff for northbound left-turning traffic.