In 1937, US 28 was truncated from Florence to Eugene, which then became its western terminus.

US 28 was replaced with US 26 when US 26 was extended from Wyoming to the Pacific Ocean in 1952.

That highway then continued in a northwesterly direction to Portland and Astoria.

US 28 began at US 99 in Eugene before continuing to Sisters and Redmond, where the route met US 97.

Continuing east, the highway traveled concurrently with US 395 between Mount Vernon and John Day.