The road continues north as it passes by South Florida Museum and Bradenton Riverwalk before crossing the Green Bridge and moving onto 8th Avenue W in Palmetto where it intersects 10th Street West, which leads to State Road 43 where the northern concurrency of U.S. Route 41 and U.S. Route 301.

The route joins State Road 60 at the one way couplet of Kennedy Boulevard (northbound) and Jackson Street (southbound).

The route continues south and 21st Street merges back with 22nd Street shortly before a parclo interchange with SR 618 (Selmon Expressway) and crosses over McKay Bay along the Licata Bridge.

The route makes a slight curve and continues east as Causeway Boulevard until it reaches its southern terminus near Port Tampa Bay at US 41 (50th Street) and State Road 676 (Causeway Boulevard).

U.S. Route 541 was created in 1931 as a western alternate to US 41 between Palmetto and Tampa; US 41 then followed the present US 301 between those points.

begins at the northern terminus of the US 41/US 129 overlap, where it shares a concurrency with Georgia State Route 49 (SR 49).

US 41 Bus./SR 19 travels south until turning west at Georgia Avenue until splitting into a one-way pair at the intersection with College Street.

From that point, northbound US 41 Bus./SR 49 continues west along Georgia Avenue until it reaches Hardeman Avenue, while southbound US 41 Bus./SR 49 travels east along Forsyth Road then turns north along College Street.

After a split-diamond interchange with Interstate 75 (I-75; exit 149) and SR 540 where the northbound routes go over the Joe A. Witherington Bridge while the southbound routes go over the Raymond Berry Oakley III Bridge, the one-way pair ends as Hardeman Avenue and Forsyth Street converge and becomes Vineville Avenue.

from the northern end of the US 80 and US 129/SR 11 concurrencies to the northern terminus, is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense.

from the southern end of the SR 16 concurrency to the northern terminus is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense.

It serves the city of Clarksville, Tennessee on its way to Nashville, where it briefly runs concurrently with US 41.

It then separates again to serve Shelbyville, Winchester, and Tullahoma before rejoining the main route atop Monteagle Mountain.

US 41A runs west of US 41 for its entire length, aside from one mile (1.6 km) in downtown Nashville, where they are concurrent.

US-41A is also concurrent with U.S. Route 31A from Nashville to Triune, Tennessee, for a distance of approximately 25 miles (40 km).

Most of the road is a two-lane highway, occasionally widening to three lanes to accommodate truck traffic on hills.

Known and referred to locally as "US 41A" but signed as "Alternate US 41," this highway follows what was the original route of US 41 between the cities of Madisonville and Henderson, Kentucky.

From that point, the highway begins its turn toward the north, passing mostly through rural areas but also serving the small communities of Dixon and Poole.

Major highways intersecting the route include: US 41A's northern terminus is at "The Cloverleaf," the interchange between US 60 and I-69/US 41 on Henderson's north side.

The segment of the highway from just north-northwest of the Henry–Clayton county line to Marietta had a "completed hard surface".

[16][17] In 1953, US 19/US 41/SR 3 was shifted eastward onto the "Expressway" (the precursor of Interstate 75 (I-75)) in the southern part of Atlanta, traveled west on Lakewood Avenue, and then resumed the northern path.

[21][22] By the end of the year, SR 3W was established, traveling northwest with US 41 on Marietta Street and Old Marietta Road, while SR 3E traveled north-northwest on Hemphill Street and Northside Drive.

[21][22] By the end of the year, SR 3E traveled north-northwest on Hemphill Street and Northside Drive.

[22][23] Later that year, all of SR 3E from Atlanta to northwest of the Fulton–Cobb county line had a completed hard surface.

[23][27] In 1940, nearly the entire segment of SR 3E in Marietta had a completed hard surface.

[28][29] By the end of the next year, the entire length of SR 3E had a completed hard surface.

The toll route entirely followed the Tri-State Tollway and Kingery Expressway from Hammond, Indiana to Wadsworth, Illinois.

41) was a state trunkline highway that served as a business loop off US 41 in Michigan through the city of Marquette along Washington and Front streets after the construction of an expressway bypass of downtown.

Jurisdiction over the two streets was transferred to the city as part of a route swap that resulted in the decommissioning of the trunkline.

US 41) served Ishpeming and Negaunee is the only one of the three former business loops in Michigan that is still a state-maintained highway, although it is no longer designated Bus.