U.S. Route 460 (US 460) is a part of the U.S. Highway System that travels from Frankfort, Kentucky, to Norfolk, Virginia.

US 460 now begins when it splits from US 60 a few miles east of downtown Frankfort.

It is a winding two-lane highway with no shoulders and intersects US 62 and I-75 at Georgetown.

It proceeds to Paris, where it serves as the town's "Main Street" and intersects US 27 and US 68.

The route enters the southwestern part of Virginia.