The hospital not only treated patients with medical conditions, but provided shelter for flood victims who had become homeless.

[2] In 1971, it became apparent that Pikeville Medical Center needed to be expanded once again in order to adequately serve the residents of Eastern Kentucky.

[2] During 2009–2011, Pikeville Medical Center was named the National Hospital of the Year by the American Alliance of Healthcare Providers three consecutive times.

As of 2018, the hospital consists of 1.6 million square feet spread across 43 facilities, is licensed for 340 beds, and has approximately 3,000 employees.

[3] On February 12, 2010, Pikeville Medical Center received a $44.6 million loan from the federal government that permitted the construction of a new 11-story clinic and parking garage.