The highway splits from US 50 in Silver Springs, heading north to Fernley and then southeast to rejoin US 50 west of Fallon.

As SR 427 heads west towards Interstate 80 and Wadsworth, US 50A/US 95A turn east to follow Main Street (old US 40) through Downtown Fernley.

[6] This action resulted in two separate highways simultaneously carrying the US 95 Alternate designation, as present-day US 95A south of Fernley had been created years earlier.

While the new number was posted along the road circa 1977 and first seen on Nevada's state highway map in the 1978 edition,[7] the designation had yet to be formally approved.

The previous alignments are as follows: Media related to U.S. Route 50 Alternate (Nevada) at Wikimedia Commons