SR 427 also provides an eastern link to Pyramid Lake via a junction with State Route 447 in Wadsworth.

SR 427 begins at a cattleguard on Cantlon Drive just south of the Wadsworth/Pyramid Lake interchange (Exit 43) on Interstate 80 (I-80) in Washoe County.

The highway proceeds northeast from there to meet State Route 447 in the middle of Wadsworth.

The route curves southeast through the town and immediately enters Lyon County.

Passing south under I-80 once again, as well as the Union Pacific railroad tracks, SR 427 curves east to follow Main Street/Truckee Lane into Fernley.