The route, known as Main Street at this point, starts from its southern terminus at its junction with US 5, just north of US 5's interchange with I-91 (exit 20).

The road keeps straight until its northern terminus at US 5 north of St. Johnsbury.

This route starts from its southern terminus at its junction with US 5, near the edge of the city limits.

The road goes northeast and meets with the South Bay on the east side.

Before the next intersection, US 5 turns northwest still as Coventry Street entering the Newport urban area.

in Derby Line, Vermont, is an alternate way to reach Canada from US 5.

This route starts from its southern terminus at its junction with US 5 in downtown Derby Line.

merges with the I-91 northbound continuing until its northern terminus at the Canada–United States border.