In retaliation, on September 18, 1675, the Indians attacked and killed Captain Thomas Lathrop and a small force in the Battle of Bloody Brook before being routed by reinforcements.

Thereafter called Bloody Brook or Muddy Brook, South Deerfield in 1809 attempted to be set off from Deerfield in part because of the distance to its meetinghouse and in part because of religious differences with its minister, the Reverend Samuel Willard.

There are a variety of retail and service establishments in South Deerfield, including a hardware store, a family restaurant, the Polish American Citizens Club, and a small brewery.

The town's Tilton Library and Frontier Regional High School are also in South Deerfield.

[4] According to the United States Census Bureau, the CDP has a total area of 8.4 km2 (3.3 mi2), of which 8.1 km2 (3.1 mi2) is land and 0.3 km2 (0.1 mi2) (3.37%) is water.

South Deerfield is home to a single unified Roman Catholic parish.

[10][11][12] A parish of the Ukrainian Greek Catholic Church, Descent of the Holy Spirit (formerly Descent of the Holy Ghost) was founded in 1920 as part of the Ukrainian Catholic Diocese of Stamford, and is active to the present day.