US 63 and US 10 then run concurrently eastward into Ellsworth's downtown area, where they encounter the southern end of WIS 65.

From Trego, US 63 proceeds northeastward towards Hayward and Ashland, passing through Earl, Springbrook, and south of Stanberry before entering Sawyer County.

Entering Bayfield County, the highway passes through Cable, south of Drummond, through Grand View, and east of Mason.

[2] With the creation of the United States Numbered Highway System in 1926, US 63, as a whole, only served as far north as Des Moines, Iowa.

[4] In 1934, US 63 was extended north from Oskaloosa, Iowa, to Ashland; its direct connection to Des Moines was replaced with the short-lived designation US 163.