U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States.

The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande.

Throughout Texas, US 67 runs in a primarily northeast–southwest manner, apparently violating the norms for numbering U.S. highways as odd-numbered routes are typically north–south in orientation, because prevailing north–south versus prevailing east–west designation is determined by the ultimate termini as the route traverses multiple states.

Though it passes through the heart of the Ozarks, the highest elevation along US 67 is the last 150 miles between Fort Stockton and Presidio.

It then runs concurrent with Interstate 57 north to US 412 in Walnut Ridge, where I-57 and the freeway ends and the road becomes a five-lane undivided highway to Pocahontas.

The bill, by Rep. J.R. Rogers of Walnut Ridge, designates US 67 in Jackson, Lawrence, and Randolph Counties as "Rock 'n' Roll Highway 67."

Besides Elvis Presley and Johnny Cash, the bill notes that Roy Orbison, Jerry Lee Lewis, and Fats Domino played at clubs along that stretch of highway.

Construction is complete to divide the highway through Wayne, Madison, and Butler Counties, including bypasses around Greenville and Cherokee Pass.

About 25 miles (40 km) north of Bonne Terre, US 67 crosses Interstate 55 and enters Festus and Crystal City and picks up US 61.

This becomes known as Truman Boulevard in Festus and Crystal City, Highway 61-67 from Herculaneum to Imperial, and Jeffco Boulevard from Arnold until it exits Jefferson County and enters St. Louis County, over the Meramec River where it becomes Lemay Ferry Road.

It runs near the cities of Jacksonville, Beardstown, through Macomb, and near Monmouth before crossing into Iowa across the Rock Island Centennial Bridge.