U.S. Route 6 (US 6) is a part of the United States Numbered Highway System that runs from California to Provincetown, Massachusetts.

The road becomes a four-lane divided highway passing south of the Porter Regional Hospital and through an interchange with SR 49.

East of SR 49, the roadway reduces back to a two-lane road, before passing over CSX Transportation's Garrett Subdivision.

In rural LaPorte County, US 6 has an intersection with SR 39 before an at grade crossing with Canadian National Railway's South Bend Subdivision.

The road crosses over CSX Transportation's Garrett Subdivision before passing northeast of Kingsford Heights.

In St. Joseph County, the road enters Walkerton and passing through the southern end of SR 104, near industrial properties.

Past La Paz, US 6 has an interchange with US 31 before narrowing back to a two-lane rural highway.

In rural Elkhart County, the road passes mostly farms, with some houses and industrial land mixed in, having an intersection with SR 15 and crosses Norfolk Southern Railway's Marion Branch .

[1][3][4] In Noble County, the roadway enters Ligonier passing some industrial properties, before the landscape sounding the road becomes commercial.

US 6 begins an overlap with SR 9 before passing over Norfolk Southern Railway's Chicago Line and through Brimfield.

Past Brimfield, the overlap ends with SR 9 turning north, while US 6 continues towards the east, heading toward Kendallville.

The road enters Kendallville, concurrent with North Street, passing industrial land, with some commercial properties, before an intersection with SR 3.

East of Waterloo, US 6 parallels Norfolk Southern Railway's Chicago Line for a short distance, before the road enters Butler, passing industrial and commercial properties.

The road crosses Norfolk Southern Railway's Huntington District before leaving Butler and entering rural DeKalb County.

In rural DeKalb County, US 6 parallels Norfolk Southern Railway's Chicago Line, passing agriculture land, before US 6 crosses into Ohio.

[5] The NHS is a network of highways that are identified as being most important for the economy, mobility, and defense of the nation.

This measurement is a calculation of the traffic level along a segment of roadway for any average day of the year.

On June 8, 1931, the American Association of State Highway Officials approved an extension of US 6 from Pennsylvania to Colorado, passing through Indiana along SR 6.

[16][17] A reroute of US 6 to its modern route in Lake County, concurrent with SR 51 and the Borman Expressway, occurred in either 1966 or 1967.