Nationally, the route continues west to Bishop, California, and east to Provincetown, Massachusetts.

In western Rhode Island, it forms part of one of several routes between Hartford, Connecticut, and Providence and was planned to be replaced by Interstate 84 (I-84).

The whole route of US 6 is a state highway maintained by the Rhode Island Department of Transportation (RIDOT).

This newer section ends as it merges with Route 101, once the Rhode Island and Connecticut Turnpike, and now called Hartford Pike.

(The Rhode Island and Connecticut Turnpike continued to the Olneyville section of Providence, where it is known as Hartford Avenue.)

The south interchange[3] of US 6 and I-295 has numerous ramp stubs once intended for a western continuation of the Roberts Expressway as I-84.

At the second US 6A interchange, the older Olneyville Bypass begins, and the freeway reduces to four lanes.

Along the connector is an interchange with Dean Street before it (and Route 10) ends at I-95, with ramps to Memorial Boulevard for downtown access.

The part of Route 3 in Rhode Island ran roughly how US 6 does now; the main differences were in Scituate (where it used US 6 Bus.)

[4] By the time Route 3 became US 6 in late 1926, it had been moved to use Waterman Avenue through East Providence to Massachusetts.

[5] (In Massachusetts, US 6 turned south on present Route 114A to reach its current alignment.)

In Downtown, Providence, it turned south on Main Street and east on Fox Point Boulevard (now I-195) to reach the bridge, taking Taunton Avenue (now US 44) into Massachusetts (where it turned south on present Route 114A).

In 1963 and 1964, I-95 was opened at the west end of I-195; the eastbound entrance from Friendship was slightly moved but otherwise remained the same.

Maps (and even some current signage) disagree about whether US 6 moved to the new bypass at that point or remained on Warren Avenue.

The Dennis J. Roberts Expressway opened in 1971, providing a bypass of US 6 from I-295 in Johnston east to Olneyville.

[15]RIDOT is in the process of renumbering exits from sequential numbering to a mileage-based system to conform with federal highway standards.

Danielson Pike, formerly known as the Foster and Scituate Turnpike, runs concurrent with US 6 and US 6 Bus.