After this, US 70S enters the urban Nashville area along Harding Pike, intersecting SR 100 and then crossing I-440 as West End Avenue.

At that interchange, the one-way couplet of US 70 and SR 24 meets US 70S, and all these routes continue into downtown Nashville.

At the intersection of Rosa Parks Boulevard and Broadway, US 31 and US 41 run concurrently with the other routes on 8th Avenue South and then Lafayette Street, while US 431 splits off with US 31 and US 41 headed north, and US 70 and SR 24 continue east.

The highway then has an interchange with Lee Victory Parkway (SR 102) and I-840 before briefly paralleling the west fork of the Stones River and entering the city of Murfreesboro.

As Dr. Martin Luther King Jr. Boulevard, and then as the John Bragg Highway, the two routes leave the city and continue east through forested areas and farmland for several miles.

In 2006, besides the two-mile (3.2 km) western terminus near Bellevue past Interstate 40 to the intersection with US 70, the only section of US 70S that lacked four lanes was between Woodbury and McMinnville.

As the remaining two-lane portion will be adjacent to the site chosen in late January 2017 by the Metropolitan Nashville-Davidson County Board of Education for the relocation of Hillwood High School,[2] this may also be upgraded.