US 83 enters North Dakota at the South Dakota state line, near the town of Hague, and runs northward for approximately 68 miles (109 km), serving the small cities of Strasburg and Linton before reaching Interstate 94 (I-94).

Headed toward Minot US 83 traverses mostly agricultural land, passing through some small cities such as Wilton, Washburn and Underwood north to Max.

Leaving Underwood, US 83 passes by the Falkirk Mine, a large strip-mining coal (lignite) operation which can be seen from the roadway in the vicinity of Falkirk; a small viaduct carried coal over the highway for several years (the Falkirk Mine serves the nearby Coal Creek Station, also visible from the highway).

North of the lakes, the surroundings return to cropland and grazing land, though a wind farm is located south of Minot.

The northbound route passes the airport and continues to Minot Air Force Base, where it returns to a two-lane highway.