Starting at a junction with Highway 42 on the eastern shore of St. Thomas, the road is about seven miles (11 km) long.

Highway 40 serves several small towns in the eastern and central parts of St. Thomas.

It enters the town on Gamle Norsidevei, until it meets Prindsesse Gade, which is one-way westbound.

Traffic is directed onto Prindsesse to Nye Norsidevei, which is one-way southbound, which then meets Dronnigens Gade (Highway 308).

[3] This article relating to roads in the U.S. Virgin Islands is a stub.