U.S. Virgin Islands Highway 66 is a major east–west arterial on St. Croix in the United States Virgin Islands and is named the Melvin H. Evans Highway in honor of the territory's first elected governor.

It is one of the few divided highways in a territory with the distinction of being the only US jurisdiction to drive on the left.

[3] All junctions are at-grade, there are stoplights with connecting roads, and driveway access is limited by default in the territory[4] but the highway is not explicitly classified as an expressway.

It is an important intermediate link between locations on the southern coast, including an oil refinery of the Hess Corporation and the Henry E. Rohlsen International Airport, and the island's principal towns Christiansted and Frederiksted.

The highway travels through areas of mostly lighter development and has multiple spurs and other intersections connecting to parallel roads and smaller communities.