[3] Her father, a member of the Communist Party of India (Marxist) (CPI (M)), was elected two times each to the Lok Sabha (1962 and 1977) and the Tamil Nadu Legislative Assembly (1977 and 1980).

Her mother, a founding member of the All India Democratic Women's Association,[4] was elected to the Tamil Nadu Legislative Assembly from the Thiruverumbur constituency in 1989.

After graduating with a bachelor's degree in commerce, Vasuki joined the Communist Party of India (Marxist) (abbreviated CPI(M) or CPM) in 1977.

[2] Vasuki unsuccessfully contested in the 2014 Indian general election from Chennai North.

[6][7] Following that, in the 2016 Tamil Nadu assembly election she contested from Madurai West and lost.