The UAAP Season 78 Men's Football Final took place on 5 May 2016 at the Rizal Memorial Stadium, featuring a matchup between UP Fighting Maroons and Ateneo Blue Eagles.

UP won 4–1, with one goal from Daniel Gadia and a hat-trick from Kintaro Miyagi, to claim their sixth UAAP Football Championship final victory; Ateneo's goal was scored by Mikko Mabanag.

The men's and women's Final matches were on May 5, 2016, which was exactly eight months after the start of the season on September 5, 2015.

The UP Fighting Maroons dedicated their win for their teammate Rogie Maglinas who had just died of cancer.

From the elimination round, Ateneo Blue Eagles and UP Fighting Maroons made to the Final Four with De La Salle Green Archers and UST Growling Tigers.