2JY5, 2JY6, 2KLC2997956085ENSG00000135018ENSMUSG00000005312Q9UMX0Q8R317NM_013438NM_053067NM_026842NM_152234NP_038466NP_444295NP_444295.1NP_081118NP_689420Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.

They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.

[8][9] Ubiquilin-1 has been reported to act as a molecular chaperone for amyloid precursor protein (APP), a protein associated with Alzheimer's disease.

[11] Two transcript variants encoding different isoforms have been found for this gene.

[7] Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.